Next Level Research - Genius

All BRAINSUPREME™ products are formulated with one overarching objective: To help you get in your "Flow State" - the mental state in which you are fully immersed in a feeling of energized focus, full involvement, and genuine enjoyment in the process of any activity - all so you can go longer, stronger and happier in the game of life.

Our Stacked-Nootropic formulations combine organic Functional Mushrooms with the highest quality amino acids, nutrients, herbs, adaptogens, and ergogenics to create powerful, rapidly noticeable results that help our BRAINSUPREME™ community achieve new heights of well-being, self-improvement, and performance.

We come up with the most effective solutions by starting with the research.  Understanding what ingredients are supported by the clearest and most robust science.  Understanding what dosages each component should have relative to the other for maximum synergistic effect.  Have a closer look at our ingredients and the science we rely upon in our formulations.

Supporting Research behind our Genius™ Product

Genius is blended to support brain function, uplift emotions, enhance focus and creativity, support neuroplasticity, and get you thinking and feeling like the genius you were born to be! Learn more about the research supporting BRAINSUPREME’s Genius Stacked-Nootropics. Ingredients are presented below in the order they appear on our packaging label:

The Brain Supreme Mushroom Blend: We grow our own organic and biodynamic functional mushrooms that make up our proprietary mushroom blend. We use purified and enriched growing substrates which provide a diverse microbiome that maximizes the genetic potential of the mushrooms and imparts potent healing properties supported by science. We develop our own proprietary genetics and WE USE ONLY THE MUSHROOM FRUITING BODIES AND NO MYCELIUM.

L-Theanine: L-theanine is a natural compound found particularly in green tea. Studies show it can increase serotonin, GABA, and dopamine. Together, these brain chemicals improve alertness, mood, and concentration.

• For a deeper dive, start with this paper found at the National Institutes of Health, National Library of Medicine, entitled: Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study. Here’s an informative excerpt from that paper to give you the gist: “Our study indicated thatl-theanine may contribute to improving attention, thus enhancing working memory and executive functions. l-theanine has been previously reported to have a neuroprotective effect. Because it suppresses delayed neuronal cell death in the hippocampal Cornu Ammonis 1 area after transient ischemia, reduces excitotoxicity by suppressing the extracellular release of glutamate through inhibition of the glutamine transporter, and promotes neurogenesis, l-theanine can potentially reduce cognitive impairment.

L-Tyrosine: Often used in nootropics, energy drinks, and supplements, studies have shown that the nonessential amino acid l-tyrosine is a precursor for the vital neurotransmitter’s dopamine, epinephrine, and norepinephrine. Researchers believe tyrosine may aid in cognitive performance, productivity, memory, learning, and is beneficial under times of severe stress or cognitive challenge.

• For a deeper dive, here’s a great article: What 11 Studies Say About The Benefits Of L-Tyrosine
• And at the National Institutes of Health, National Library of Medicine: Food for thought: association between dietary tyrosine and cognitive performance in younger and older adults. Here’s an informative excerpt from that paper to give you the gist: “The fact tyrosine increases dopamine availability that, in turn, may enhance cognitive performance has led to numerous studies on healthy young participants taking tyrosine as a food supplement. As a result of this dietary intervention, participants show performance increases in working memory and executive functions.”

Alpha GPC: Alpha-GPC seems to increase the levels of a chemical in the brain called acetylcholine. This brain chemical is important for memory and learning functions. For a deeper dive, here are a couple papers at the National Institutes of Health, National Library of Medicine:

• The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility. “Alpha-GPC administration increases the release of the neurotransmitter acetylcholine and facilitates learning and memory.”
• Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study. “αGPC treatment show a tendency to increase motivation during the intervention period. Furthermore, motivation at night was significantly higher in the αGPC group than in the placebo group”.

Lion’s Mane Extract: Lion’s Mane stimulates enzyme production that releases Nerve Growth Factor (NGF). Nerve Growth Factor helps repair damaged neurons in the brain and boosts the growth of new neurons (neurogenesis) for better learning and memory. Recent research on Lion’s Mane indicates it may be the single most effective natural product capable of growing new brain cells and stimulating repair and regrowth of existing brain cells. Such research includes the following:

• Lion’s Mane mushroom has been shown to magnify memory by boosting brain nerve growth:
• From the Journal of Neurochemistry - Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory. Here’s an excerpt of that research: “…were highly potent in promoting extensive axon outgrowth and neurite branching in cultured hippocampal neurons even in the absence of serum, demonstrating potent neurotrophic activity.” “resulting in significantly enhanced hippocampal memory. Hericene A (Lion’s Mane) therefore acts through a novel pan-neurotrophic signaling pathway,leading to improved cognitive performance.” And from the same article: “Here we demonstrate that crude and purified extracts of the nootropic mushroomH. erinaceus (Lion’s Mane) have BDNF-like neurotrophic activity (BDNF = Brain Derived Neurotrophic Factor) both in cultured hippocampal neurons and in paradigm models of learning in vivo, leading to marked neurite outgrowth and improved memory”:

Bacopa: Studies show bacopa monnieri is beneficial for improving information processing, speeding up the brain, reducing reaction times, and supporting memory. Here is supporting research from the National Institutes of Health, National Library of Medicine:

• Efficacy of Standardized Extract of Bacopa monnieri (Bacognize®) on Cognitive Functions of Medical Students. Here’s an excerpt: “ Statistically significant improvement was seen in the tests relating to the cognitive functions with use ofBacopa monnieri.”
• Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation. Here’s an excerpt: “Overall, this review provides deeper insights into the therapeutic implications of Brahmi as a lead formulation for treating neurological disorders and exerting cognitive-enhancing effects. And from the conclusion section: “The neuroprotective properties of these bioactive components include reduction of Reactive Oxygen Species (ROS), neuroinflammation, inhibition of amyloid-β and improvement of cognitive and learning behavior.”

Niacin: Research at Harvard suggests Niacin is believed to protect brain cells from stress and injury. What is also emerging is that niacin bioavailability is crucial for neuron survival and functions: indeed, vitamin deficiency has been recognized as a pathogenic factor for neurological deficits and dementia, as well as for neuronal injury and psychiatric disorders. Niacin may also reduce neuroinflammation. Research also suggests niacin may facilitate neurobehavioral recovery and brain plasticity following central nervous system diseases such as stroke, Alzheimer’s disease, and Multiple Sclerosis. Our brains also need niacin as a part of the coenzymes NAD and NAD+, which are required for energy and proper brain function.